FK866 inhibits colorectal cancer metastasis by reducing NAD + levels in cancer-associated fibroblasts.

Hanhan XieYun LeiYushan MaoJingbin LanJing YangHui QuanTao Zhang

Published in: Genes & genomics (2022)

synthesis by FK866 may decrease the activation and stemness of CAFs, reduce the secretion of inflammatory and chemokines by suppressing the expression of PITX3, resulting in the suppression of colorectal cancer metastasis.

Keyphrases

stem cells
epithelial mesenchymal transition
oxidative stress
extracellular matrix
binding protein
signaling pathway
cancer stem cells