Maternal diet during gestation affect prostatic tissue component in SHR/Izm offspring.
Kosuke ShibamoriYuki KyodaTetsuya ShindoKohei HashimotoKo KobayashiToshiaki TanakaHiromu SuzukiNaoya MasumoriPublished in: The Prostate (2023)
Our findings suggest that both maternal undernutrition and obesity influence the prostatic development of offspring. Maternal consumption of a low protein diet promotes epithelial hyperplasia through the upregulation of apoptosis inhibitors, while a high fat diet leads to increased stromal growth through the induction of EMT.
Keyphrases
- high fat diet
- insulin resistance
- birth weight
- weight loss
- adipose tissue
- pregnancy outcomes
- physical activity
- weight gain
- gestational age
- metabolic syndrome
- type diabetes
- benign prostatic hyperplasia
- oxidative stress
- radical prostatectomy
- bone marrow
- skeletal muscle
- cell proliferation
- high fat diet induced
- pregnant women
- preterm infants
- cell death
- signaling pathway
- body mass index
- binding protein
- preterm birth
- small molecule
- long non coding rna
- pi k akt