The results suggest that SPAGI can be a useful approach to identify the potential active signaling pathways given a gene expression profile. Our method is implemented as an open source R package, available via https://github.com/VCCRI/SPAGI/ .
Keyphrases
- signaling pathway
- gene expression
- pi k akt
- dna methylation
- electronic health record
- epithelial mesenchymal transition
- copy number
- big data
- induced apoptosis
- human health
- cell proliferation
- binding protein
- machine learning
- amino acid
- risk assessment
- genome wide identification
- transcription factor
- oxidative stress
- genome wide analysis