Asthma is a chronic condition that affects children worldwide. Accumulating number of studies reported that the prevalence of pediatric obesity and asthma might be altered through breastfeeding. It has been proposed that Leptin, which exists in human milk, is oppositely associated with weight increase in newborns. It may also influence peripheral immune system by promoting TH1 responses and suppressing TH2 cytokines. Leptin influences body weight and immune responses through complex signaling pathways at molecular level. Although previous studies provide explanations for the protective role of breastfeeding against both obesity and asthma, other factors such as duration of breastfeeding, parental, and prenatal factors may confound this relationship which requires further research.
Keyphrases
- chronic obstructive pulmonary disease
- weight loss
- body weight
- lung function
- human milk
- insulin resistance
- metabolic syndrome
- preterm infants
- weight gain
- low birth weight
- allergic rhinitis
- type diabetes
- immune response
- high fat diet induced
- signaling pathway
- pregnant women
- young adults
- risk factors
- adipose tissue
- cystic fibrosis
- case control
- toll like receptor
- skeletal muscle
- epithelial mesenchymal transition
- cell proliferation
- gestational age