Blood Lipids and the Risk of Colorectal Cancer: Mendelian Randomization Analyses in the Japanese Consortium of Genetic Epidemiology Studies.

Masao Iwagami Atsushi Goto Ryoko Katagiri Yoichi Sutoh Yuriko N Koyanagi Masahiro Nakatochi Shiori Nakano Akiko Hanyuda Akira Narita Atsushi Shimizu Kozo Tanno Atsushi Hozawa Kengo Kinoshita Isao Oze Hidemi Ito Taiki Yamaji Norie Sawada Yohko Nakamura Sho Nakamura Kiyonori Kuriki Sadao Suzuki Asahi Hishida Yumiko Kasugai Issei Imoto Midori Suzuki Yukihide Momozawa Kenji Takeuchi Masayuki Yamamoto Makoto Sasaki Keitaro Matsuo Shoichiro Tsugane Kenji Wakai Motoki Iwasaki

Published in: Cancer prevention research (Philadelphia, Pa.) (2022)

In this large MR analysis of a Japanese population, a positive association was found between genetically predicted high total cholesterol (TC) levels and an increased risk of colorectal cancer. Therefore, lowering TC levels by lifestyle modifications or medications may be justified for the purpose of preventing colorectal cancer.

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