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In Vivo Molecular Signatures of Cerebellar Pathology in Spinocerebellar Ataxia Type 3.

Maria do Carmo CostaMaria RadzwionHayley S McLoughlinNaila S AshrafSvetlana FischerVikram G ShakkottaiPatrícia MacielHenry L PaulsonGülin Öz
Published in: Movement disorders : official journal of the Movement Disorder Society (2020)
N-acetylaspartate, myo-inositol, and total choline levels in the cerebellum are candidate biomarkers of neuroaxonal and oligodendrocyte pathology in SCA3, aspects of pathology that are reversible by RNAi therapy. © 2020 International Parkinson and Movement Disorder Society.
Keyphrases
  • genome wide
  • gene expression
  • dna methylation
  • replacement therapy