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Leptin Rs7799039 polymorphism is associated with type 2 diabetes mellitus Egyptian patients.

Amal Ahmed MohamedDina M Abo-ElmattyAlaa S WahbaOmnia Ezzat EsmailHadeer Saied Mahmoud SalimWafaa Salah Mohammed HegabMona Mostafa Farid GhanemNadia Youssef RiadDoaa GhaithLamiaa I DakerShorouk IssaNoha Hassan RadwanEman SultanOmar Mohamoud AzzamEhab A M El-Shoura
Published in: Archives of physiology and biochemistry (2023)
The genetic polymorphism rs7799039 showed a highly significant correlation with blood LEP. The co-dominant and dominant models of the LEP genetic polymorphism (rs7799039, 2548 G/A) were shown to have a significant correlation with complicated and uncomplicated diabetes individuals, but we have found that serum LEP levels were inversely related with control and diabetes patients. A positive significant association was found between LEP genetic polymorphism (rs7799039, 2548 G/A) and serum LEP in patients and controls. LEP levels and its rs7799039 genetic variant may play a vital role in increasing T2DM susceptibility.
Keyphrases
  • ejection fraction
  • newly diagnosed
  • type diabetes
  • cardiovascular disease
  • genome wide
  • prognostic factors
  • glycemic control
  • patient reported outcomes
  • copy number
  • weight loss
  • cardiovascular risk factors