Primary chest wall Burkitt lymphoma in a case of HIV infection with immune reconstitution.
Arihant JainVijayalakshmi Aravindan ArunAmanjit BalPankaj MalhotraPublished in: BMJ case reports (2021)
Burkitt lymphoma (BL) develops at an increased frequency in patients with HIV irrespective of the CD4 count. Lymph nodes and gastrointestinal tract are common sites of involvement by BL; however, primary chest wall BL is rare. A 52-year-old man on highly active antiretroviral therapy (HAART) for HIV with a CD4 count of 0.204 x 10 9 cells/L presented with a 3-month history of enlarging chest wall mass. PET-CT scan imaging showed a bulky mass involving the musculoskeletal planes of left chest wall with the involvement of underlying pleura. Biopsy with immunohistochemistry confirmed BL. Patient received EPOCH-R (infusional etoposide, vincristine, and doxorubicin with prednisone, cyclophosphamide and rituximab) regime for six cycles along with HAART, attained complete remission (CR) and remains free of BL at 5 years. BL should be considered in the differential diagnosis of soft tissue masses in HIV-infected patients irrespective of their CD4 count.
Keyphrases
- antiretroviral therapy
- hiv infected patients
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- pet ct
- diffuse large b cell lymphoma
- lymph node
- peripheral blood
- soft tissue
- computed tomography
- high dose
- high resolution
- induced apoptosis
- systemic lupus erythematosus
- positron emission tomography
- case report
- ultrasound guided
- cell proliferation
- oxidative stress
- drug delivery
- early stage
- fine needle aspiration
- endoplasmic reticulum stress
- cell cycle arrest