Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response.

K García-MartínezJ ChenJ JonesA WooA AucapinaI BritoCynthia A Leifer

Published in: bioRxiv : the preprint server for biology (2023)

Nucleic acid-sensing TLRs contribute to development and progression of autoimmune disease including interferonopathies, and we show a novel role for STING in TLR-induced IFN production that could be a therapeutic target.

Keyphrases

toll like receptor
nucleic acid
immune response
inflammatory response
dendritic cells
nuclear factor
high glucose
drug induced
diabetic rats
endothelial cells
genome wide
gene expression
dna methylation
transcription factor