Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer.

Yu-Ra ChoiEun Hye KangSunshin KimSeog-Yun ParkJi-Youn HanYoung Joo Lee

Published in: British journal of cancer (2023)

Single MET inhibition produced a short-lived response in EGFR-mutant and MET-amplified lung cancer. A further study of a novel combination therapy schedule is needed to achieve long-lasting efficacy and less toxicity.

Keyphrases

tyrosine kinase
combination therapy
epidermal growth factor receptor
small cell lung cancer
oxidative stress
cancer therapy
drug delivery