Virulence Factor Genes in Invasive Escherichia coli Are Associated with Clinical Outcomes and Disease Severity in Patients with Sepsis: A Prospective Observational Cohort Study.
Valentino D'OnofrioReinoud CartuyvelsPeter E A MessiaenIvan BarisicInge C GyssensPublished in: Microorganisms (2023)
Microcins, toxins, and fimbriae were associated with disease severity. Adhesins and iron uptake proteins seemed to be protective. Two genes were associated with worse clinical outcome. These findings contribute to a better understanding of host-pathogen interactions and could help identifying patients most at risk for a worse outcome.
Keyphrases
- escherichia coli
- end stage renal disease
- genome wide
- newly diagnosed
- ejection fraction
- chronic kidney disease
- intensive care unit
- biofilm formation
- pseudomonas aeruginosa
- staphylococcus aureus
- prognostic factors
- acute kidney injury
- peritoneal dialysis
- bioinformatics analysis
- candida albicans
- dna methylation
- cystic fibrosis
- patient reported