Correlation of alpha-1 antitrypsin levels and exosome associated neutrophil elastase endothelial injury in subjects with SARS-CoV2 infection.

Jorge LascanoRegina OshinsChristina EaganZerka WadoodXiao QiangTammy FlaggYogesh ScindiaBorna MehradMark BrantlyNazli Khodayari

Published in: PloS one (2022)

Our results point out the role of exosome-associated NE in exacerbation of endothelial injury in SARS-CoV-2 infection. We have demonstrated that exosome-associated NE could be served as a new potential therapeutic target of severe systemic manifestations of SARS-CoV-2 infection.

Keyphrases

respiratory syndrome coronavirus
endothelial cells
chronic obstructive pulmonary disease
sars cov
early onset
coronavirus disease
intensive care unit
respiratory failure