MAD2B blunts chronic unpredictable stress and corticosterone stimulation induced-depression-like behaviors in mice.

Xiao-Lan WangCheng MiaoYanfang SuChun ZhangXianfang Meng

Published in: The international journal of neuropsychopharmacology (2022)

Our results suggest an important role of neuronal MAD2B in the pathogenesis of depression via the miR-29b-3p/ GRM4 signaling pathway. MAD2B could be a potential therapeutic target for depressive disorders.

Keyphrases

stress induced
signaling pathway
depressive symptoms
sleep quality
high glucose
drug induced
epithelial mesenchymal transition
bipolar disorder
pi k akt
high fat diet induced
type diabetes
induced apoptosis
climate change
oxidative stress
skeletal muscle
endothelial cells
human health
physical activity