The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease.
Daniela GuisadoSayali TalwareXiaoli WangAndrew DavisElbek FozilovAaron EtraJean Frederic ColombelChristoph SchanielChristopher TastadJohn E LevineJames L M FerraraLing-Shiang ChuangKsenija SabicShishir SinghBridget K MarcellinoRonald HoffmanJudy H ChoLouis J CohenPublished in: bioRxiv : the preprint server for biology (2024)
These studies indicate that SCT serves as a myeloid-directed cellular therapy re-establishing homeostatic intestinal macrophages that support intestinal healing and suggest refractory CD evolves from impairment of restorative functions in myeloid cells. Furthermore, we report heterogeneity among HSCs from CD patients which may drive SCT outcomes and suggests an unrecognized impact of CD pathophysiology on HSC in the marrow niche.
Keyphrases
- stem cell transplantation
- end stage renal disease
- high dose
- dendritic cells
- bone marrow
- chronic kidney disease
- ejection fraction
- newly diagnosed
- induced apoptosis
- peritoneal dialysis
- cell cycle arrest
- stem cells
- cell proliferation
- skeletal muscle
- immune response
- oxidative stress
- signaling pathway
- mesenchymal stem cells
- weight loss
- pi k akt