Myasthenia Gravis Lambert-Eaton overlap syndrome induced by nivolumab in a metastatic melanoma patient.
Alexandra DuplaineCamille ProtGwendal Le MassonAntoine SoulagesFanny DuvalCaroline DutriauxSorilla PreyPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)
We describe the first case of MG-LE overlap syndrome diagnosed after anti-PD1 immunotherapy for metastatic melanoma, which appeared after radiation therapy and then relapsed after brain radiation necrosis. We hypothesized a role for brain inflammation as a trigger for MG-LE onset. Neuro-muscular junctions disease induced or revealed by checkpoint inhibitors can be challenging and requires long-term follow-up.
Keyphrases
- myasthenia gravis
- case report
- radiation therapy
- resting state
- white matter
- oxidative stress
- acute lymphoblastic leukemia
- dna damage
- acute myeloid leukemia
- functional connectivity
- high glucose
- diabetic rats
- multiple myeloma
- cell cycle
- single molecule
- resistance training
- multiple sclerosis
- drug induced
- endothelial cells