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Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms.

Chaozhuang ShenHongyi YangWenxin ShaoLiang ZhengWei ZhangHaitang XieXuehua JiangLing Wang
Published in: Pharmaceutical research (2024)
In clinical practice, the impact of genotyping on the in vivo disposition process of VEN should be considered to ensure the safety and efficacy of treatment.
Keyphrases
  • clinical practice
  • genome wide
  • high throughput
  • emergency department
  • genome wide identification
  • adverse drug
  • transcription factor
  • replacement therapy