Doxorubicin-Loaded Microalgal Delivery System for Combined Chemotherapy and Enhanced Photodynamic Therapy of Osteosarcoma.
Xueying AnDanni ZhongWenshu WuRuoxi WangLin YangQing JiangMin ZhouXingquan XuPublished in: ACS applied materials & interfaces (2024)
Osteosarcoma (OS) is considered the most frequent type of primary malignant bone tumor. Currently, radiotherapy, photodynamic (PDT), and other therapies for osteosarcoma are limited by tumor hypoxia and single efficacy and serve side-effects. Herein, we reported a microalgal drug delivery system (SpiD), doxorubicin (DOX)-loaded Spirulina platensis (Spi) for OS therapy. The specific surface of Spirulina platensis allowed for effective loading of DOX via surface channels and electrostatic interactions. Under 650 nm laser irradiation, SpiD enabled high oxygen production by photosynthesis and enhanced reactive oxygen species (ROS) generation via chlorophyll-assisted photosensitization, synergistically killing tumor cells with the released DOX. Combined chemotherapy and enhanced PDT mediated by SpiD exerted synergic antitumor effects and resulted in potent therapeutic efficacy in orthotopic osteosarcoma mice. Furthermore, SpiD could reduce the side-effects of chemotherapy, showing excellent blood and tissue safety. Taken together, this microalgal drug delivery system provided a natural, efficient, safe, and inexpensive strategy for OS treatment.
Keyphrases
- photodynamic therapy
- cancer therapy
- locally advanced
- drug delivery
- reactive oxygen species
- fluorescence imaging
- radiation therapy
- squamous cell carcinoma
- radiation induced
- early stage
- cell death
- endothelial cells
- type diabetes
- bone mineral density
- adipose tissue
- wound healing
- mass spectrometry
- cell therapy
- soft tissue
- high resolution
- high speed
- replacement therapy
- energy transfer