NH 3 -SCR (SCR: Selective catalytic reduction) is an effective technology for the de-NO x process from both mobile and stationary pollution sources, and the most commonly used catalysts are the vanadia-based catalysts. An innovative V 2 O 5 -CeO 2 /TaTiO x catalyst for NO x removal was prepared in this study. The influences of Ce and Ta in the V 2 O 5 -CeO 2 /TaTiO x catalyst on the SCR performance and physicochemical properties were investigated. The V 2 O 5 -CeO 2 /TaTiO x catalyst not only exhibited excellent SCR activity in a wide temperature window, but also presented strong resistance to H 2 O and SO 2 at 275 ℃. A series of characterization methods was used to study the catalysts, including H 2 -temperature programmed reduction, X-ray photoelectron spectroscopy, NH 3 -temperature programmed desorption, etc. It was discovered that a synergistic effect existed between Ce and Ta species. The introduction of Ce and Ta enlarged the specific surface area, increased the amount of acid sites and the ratio of Ce 3+ , (V 3+ +V 4+ ) and O α , and strengthened the redox capability which were related to synergistic effect between Ce and Ta species, significantly improving the NH 3 -SCR activity.