A Bayesian analysis for investigating the association between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes.

Ali Reza Soltanian Bistoon Hosseini Hossein Mahjub Fatemeh Bahreini Mohammad Ebrahim Ghaffari

Published in: Journal of diabetes and metabolic disorders (2020)

Our findings show that, rs13266634 polymorphism was associated with the type 2 diabetes risk in the population of Eastern Azerbaijan province; however, the low number of TT homozygous genotypes affected the precision of the results. Also, the deviation from HWE affected the results. It is recommended to perform further studies to establish Hardy-Weinberg equilibrium. The inconsistency in the results may be due to the ignorance of this equilibrium.

Keyphrases

type diabetes
south africa
molecular dynamics
glycemic control
molecular dynamics simulations
cardiovascular disease
insulin resistance
genome wide
gene expression
skeletal muscle
case control
dna methylation
weight loss