Bis(cholyl)-based chloride channels with oxalamide and hydrazide selectivity filters.

We report the development of supramolecular bis(cholyl) ion channels using oxalamide and hydrazide as selectivity filters. The hydrazide system showed superior chloride transport activity to oxalamide via the formation of a barrel stave channel. The better chloride recognition within the hydrazide channel over the oxalalmide channel was confirmed from the theoretical calculations.