Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes.

Mengyao LiuMartin NgTuan PhuLaura BouchareychasBrian T FeeleyHubert T KimRobert L RaffaiXuhui Liu

Published in: Stem cell research & therapy (2023)

Results from our study demonstrated that polarized macrophages directly regulated FAP differentiation through their exosomes and M2 macrophage-derived exosomes may serve as a novel treatment option for RC muscle atrophy and fatty infiltration.

Keyphrases

mesenchymal stem cells
stem cells
skeletal muscle
adipose tissue
transcription factor
bone marrow
type diabetes
combination therapy