Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease.

Xiaolian YeLu ChenHe WangShixiao PengMengjia LiuLiyang YaoYizhi ZhangYun Stone ShiYing CaoJian-Jun YangGui-Quan Chen

Published in: Neuropathology and applied neurobiology (2022)

Neuron-specific deletion of PDK1 robustly ameliorates AD-like pathology and improves spatial working memory in 5×FAD mice. We propose that genetic approach to inhibit PDK1 may be an effective strategy to slow AD.

Keyphrases

working memory
mouse model
genome wide
transcranial direct current stimulation
attention deficit hyperactivity disorder
copy number
coronary artery disease
cognitive decline
type diabetes
metabolic syndrome
gene expression
skeletal muscle
insulin resistance
wild type