Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [18F]JNJ42259152 PET study in rats.

Bart de LaatYvonne E KlingGwen SchroyenMaarten OomsJacob M HookerGuy BormansKoen Van LaereJenny Ceccarini

Published in: European journal of nuclear medicine and molecular imaging (2021)

This study shows that chronic voluntary alcohol consumption induces a reversible increased PDE10A enzymatic availability in the striatum, which is related to the amount of alcohol preference. Thus, PDE10A-mediated signaling plays an important role in modulating the reinforcing effects of alcohol, and the data suggest that PDE10A inhibition may have beneficial behavioral effects on alcohol intake.

Keyphrases

alcohol consumption
computed tomography
signaling pathway
nitric oxide
big data
electronic health record
hydrogen peroxide
pet imaging
weight loss