Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9.

Fei YanYue TengXiaoyou LiYuejiao ZhongChunyi LiFeng YanXia He

Published in: Cancer biology & therapy (2024)

Hypoxia induced the lactylation of SOX9 to promote stemness, migration, and invasion via promoting glycolysis. The findings suggested that targeting hypoxia may be an effective way for NSCLC treatment and reveal a new mechanism of hypoxia in NSCLC.

Keyphrases

stem cells
small cell lung cancer
endothelial cells
single cell
epithelial mesenchymal transition
transcription factor
advanced non small cell lung cancer
cell therapy
gene expression
cancer therapy
genome wide
cancer stem cells
mesenchymal stem cells
drug delivery
dna methylation