Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15.

Rachel M McQuadeVanesa StojanovskaRhian StavelyCara TimpaniAaron C PetersenRaquel AbaloJoel C BornsteinEmma RybalkaKulmira Nurgali

Published in: British journal of pharmacology (2018)

Our results showed that BGP-15 ameliorated oxidative stress, increased enteric neuronal survival and alleviated oxaliplatin-induced intestinal dysfunction, suggesting that BGP-15 may relieve the gastrointestinal side effects of chemotherapy.

Keyphrases

oxidative stress
diabetic rats
high glucose
dna damage
drug induced
cerebral ischemia
squamous cell carcinoma
endothelial cells
combination therapy
signaling pathway
free survival
stress induced