A brand-new cardiorenal syndrome in the COVID-19 setting.
Mugurel ApetriiStefana EnacheDimitrie SiriopolAlexandru BurlacuAsiye KanbayMehmet KanbayDragos ScripcariuAdrian CovicPublished in: Clinical kidney journal (2020)
Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient's lungs, recent data have documented that COVID-19 causes myocarditis, acute myocardial infarction, exacerbation of heart failure and acute kidney injury. Studies show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to its predecessor SARS-CoV, engages angiotensin-converting enzyme 2 (ACE2) as the entry receptor. ACE2 is also expressed in the heart, providing a link between coronaviruses and the cardiovascular system.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- angiotensin converting enzyme
- coronavirus disease
- angiotensin ii
- heart failure
- respiratory tract
- acute myocardial infarction
- acute kidney injury
- case report
- chronic obstructive pulmonary disease
- left ventricular
- mental health
- healthcare
- cardiac surgery
- big data
- acute coronary syndrome
- machine learning
- cardiac resynchronization therapy
- acute heart failure