Comparison of fully-automated radiosyntheses of [11C]erlotinib for preclinical and clinical use starting from in target produced [11C]CO2 or [11C]CH4.

Cécile PhilippeSeverin MairingerVerena PichlerJohann StanekLukas NicsMarkus MitterhauserMarcus HackerThomas WanekOliver LangerWolfgang Wadsak

Published in: EJNMMI radiopharmacy and chemistry (2018)

This study compared two synthetic protocols for the production of [11C]erlotinib with in-target produced [11C]CO2 or [11C]CH4. Both methods reliably yielded sufficiently high product amounts for preclinical and clinical use.

Keyphrases

advanced non small cell lung cancer
epidermal growth factor receptor
machine learning
room temperature
deep learning
stem cells
mesenchymal stem cells