Clinical utility of BRCA and ATM mutation status in circulating tumour DNA for treatment selection in advanced pancreatic cancer.

Kentaro SudoYoshiaki NakamuraMakoto UenoMasayuki FurukawaNobumasa MizunoYasuyuki KawamotoNaohiro OkanoKumiko UmemotoAkinori AsagiMasato OzakaKoushiro OhtsuboSatoshi ShimizuNobuhisa MatsuhashiShinji ItohToshihiko MatsumotoTaroh SatohHiroyuki OkuyamaMasahiro GotoHiroko HasegawaYoshiyuki YamamotoJustin I OdegaardHideaki BandoTakayuki Yoshino Masafumi IkedaChigusa Morizane

Published in: British journal of cancer (2024)

Comprehensive ctDNA profiling provides clinically relevant information regarding HRD status. It can be a practical, convenient option for HRD screening in APC.

Keyphrases

circulating tumor
dna damage
cell free
single molecule
single cell
healthcare
dna damage response
oxidative stress
nucleic acid
social media
replacement therapy