Bias in case-crossover studies of medications due to persistent use: A simulation study.

Katsiaryna Bykov Shirley V Wang Nina Sahlertz Kristiansen Jesper HallasMalcolm MaclureJoshua J Gagne

Published in: Pharmacoepidemiology and drug safety (2020)

Investigators should be aware of bias due to treatment persistence in unidirectional case-crossover analyses of chronic medications, which can be remedied with a control group of similarly persistent noncases.

Keyphrases

open label
double blind
placebo controlled
case control
replacement therapy