Assessing the differential impact of chronic CMV and treated HIV infection on CD8+ T-cell differentiation in a matched cohort study: is CMV the key?
Matthias C MuellerWinfried V KernSusanne UsadelMarie-Christin PaulyToni CathomenUlrich SalzerPublished in: AIDS research and therapy (2021)
CMV infection is associated with phenotypic signs of T-cell senescence, promoting exacerbation and persistence of alterations of the T-cell compartment in PLWH on effective ART, which are associated with adverse clinical outcomes and may be an attractive target for therapeutic interventions.