Concurrent Joint Contact in Anterior Cruciate Ligament Injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis.

Kei TakahataYu-Yang LinBenjamin Osipov Kohei Arakawa Saaya Enomoto Blaine A Christiansen Takanori Kokubun

Published in: bioRxiv : the preprint server for biology (2024)

Concurrent joint contact during ACL rupture caused initial micro-damage on the cartilage surface and early cartilage degeneration with MMP-13 production, leading to later bone formation in the subchondral bone.

Keyphrases

knee osteoarthritis
anterior cruciate ligament
extracellular matrix
bone mineral density
locally advanced
soft tissue
oxidative stress
bone regeneration
postmenopausal women
squamous cell carcinoma
body composition
cell migration
temporal lobe epilepsy