Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice.
Jiaojiao ChengXiangyan RuanYanglu LiJuan DuFengyu JinMuqing GuQi ZhouXin XuYu YangHusheng WangAlfred Otto MueckPublished in: Stem cell research & therapy (2022)
This is the first study to demonstrate that co-transplantation of hypoxia-preconditioned HucMSC with ovarian tissue improved earlier vascularization of ovarian grafts in the early post-grafting period, which correlates with increased follicle survival and reduced apoptosis. The HIF1α/VEGFA signal pathways may play an important role in elucidating the mechanisms of action of hypoxia-preconditioned HucMSCs with regard to OT and clinical implementation.
Keyphrases
- endothelial cells
- vascular endothelial growth factor
- primary care
- healthcare
- oxidative stress
- free survival
- endoplasmic reticulum stress
- cell death
- stem cells
- high fat diet induced
- functional connectivity
- metabolic syndrome
- induced pluripotent stem cells
- pregnant women
- cell proliferation
- signaling pathway
- tissue engineering