Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice.
Munemasa NagaoAkihisa FukudaMayuki OmatsuMio NamikawaMakoto SonoYuichi FukunagaTomonori MasudaOsamu ArakiTakaaki YoshikawaSatoshi OgawaKenji MasuoNorihiro GotoYukiko HiramatsuYu MutaMotoyuki TsudaTakahisa MarunoYuki NakanishiMakoto Mark TaketoJorge FerrerTatsuaki TsuruyamaYasuni NakanumaKojiro TauraShinji UemotoHiroshi SenoPublished in: Cancer research (2022)
This work shows how dysregulation of canonical cell growth pathways drives precursors to biliary cancers and identifies several molecular vulnerabilities as potential therapeutic targets in these precursors to prevent oncogenic progression.