A range of 30%-62% of functioning multiciliated airway cells is sufficient to maintain ciliary airway clearance.

Niki T LogesJune Kehlet MarthinJohanna RaidtHeike OlbrichInga M HöbenSandra CindricDiana BrachtJulia KönigCynthia RieckSebastian GeorgeTim Luis KlothKai WohlgemuthPetra PennekampBernd DworniczakMathias Geldermann HolgersenJobst RömelChristian SchmalstiegIsabella ApreaJann MortensenKim G NielsenHeymut Omran

Published in: The European respiratory journal (2024)

Our findings indicate that 30%-62% of functioning multiciliated respiratory cells are able to generate either normal or slightly reduced ciliary clearance. Because heterozygous females displayed either no or subtle respiratory symptoms, complete correction of 30% of cells by precision medicine might be able to improve ciliary airway clearance in PCD individuals as well as clinical symptoms.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
early onset
sleep quality
respiratory tract
pi k akt