Poly(ADP-Ribose) Polymerase Enhances Infiltration of Mononuclear Cells in Primary Sjögren's Syndrome Through Interferon-Induced Protein With Tetratricopeptide Repeats 1-Mediated Up-Regulation of CXCL10.
Qingqing TianHan ZhaoHanzhi LingLi SunChipeng XiaoGuoyu YinXiaobing WangGan WuChenglin YangMu ChenShengwei JinXinyu YangJianguang WangPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
This study is the first to implicate PARP-9 as a regulator of infiltration of mononuclear cells in primary SS progression and to reveal that PARP-9 increases CXCL10 expression through up-regulating IFIT-1, which is mediated by the phosphorylation of STAT1. PARP-9 might therefore be a novel therapeutic target for primary SS.
Keyphrases
- induced apoptosis
- dna damage
- dna repair
- cell cycle arrest
- peripheral blood
- endoplasmic reticulum stress
- oxidative stress
- dendritic cells
- gene expression
- cell proliferation
- signaling pathway
- genome wide
- rheumatoid arthritis
- single cell
- long non coding rna
- drug induced
- case report
- protein protein
- structural basis
- protein kinase