Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity.

Xiaoxia XiaoHuiling HuYadi ZhongYingjian ChenKaijia TangZhisen PanJiawen HuangXiaoying YangQi WangYong Gao

Published in: Molecular medicine (Cambridge, Mass.) (2023)

Collectively, our results revealed that microglial Sirt6 was a primary contributor of microglial activation in the central regulation of obesity. Thus, microglial Sirt6 may be an important therapeutic target for obesity.

Keyphrases

high fat diet induced
insulin resistance
inflammatory response
oxidative stress
metabolic syndrome
neuropathic pain
weight loss
lipopolysaccharide induced
lps induced
type diabetes
ischemia reperfusion injury
adipose tissue
skeletal muscle
single cell
transcription factor
physical activity
spinal cord injury