Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy.

Xinfang XieJingyi LiPan LiuManliu WangLi GaoFeng WanJicheng LvHong ZhangJing Jin

Published in: Journal of the American Society of Nephrology : JASN (2022)

We constructed a chimeric fusion of IgA protease with Fc and demonstrated its long-lasting efficacy as a promising targeted therapy for IgA nephropathy in mouse models.

Keyphrases

mouse model
cell therapy
stem cells
cancer therapy
mesenchymal stem cells
drug delivery
bone marrow