Does inbreeding contribute to pregnancy loss in Thoroughbred horses?

Jessica M Lawson Charlotte A Shilton Victoria Lindsay-McGeeAndroniki PsifidiD Claire Wathes Terje Raudsepp Amanda M de Mestre

Published in: Equine veterinary journal (2024)

This first study of the effect of genomic inbreeding levels on pregnancy loss showed that inbreeding is a contributor to MLPL, but not EPL in the UK Thoroughbred population. Mating choices remain critical, because inbreeding may predispose to MLPL by increasing the risk of homozygosity for specific lethal allele(s).

Keyphrases

preterm birth
pregnancy outcomes
copy number
gene expression
genome wide