Segregation analysis identifies specific alpha-defensin (DEFA1A3) SNP-CNV haplotypes in predisposition to IgA nephropathy.

Nzar A A ShwanEric C MoisePaula E NecsoiuAmy J FarrDaniel P GaleJonathan BarrattJohn A L Armour

Published in: Annals of human genetics (2022)

We observed overtransmission of 3-copy class 2 haplotypes (raw p = 0.029) and some evidence for under-transmission of 3-copy class 1 haplotypes (raw p = 0.051), although these apparent effects were not statistically significant after correction for testing of multiple haplotypes.

Keyphrases

genome wide
magnetic resonance imaging
computed tomography
dna methylation
diffusion weighted imaging
contrast enhanced