Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification.
Xiaoxuan ZhaiShengchuan CaoJiali WangBao QiaoXuehao LiuRui HuaMenglin ZhaoShukun SunYu HanShuo WuJiaojiao PangQiuhuan YuanBailu WangTonghui XuShujian WeiYu-Guo ChenPublished in: Circulation (2024)
Our results suggest that 4-HNE increases Runx2 stabilization by directly carbonylating its K176 site and promotes vascular calcification. ALDH2 might be a potential target for the treatment of vascular calcification.