Tuberous Sclerosis Complex-1 (TSC1) contributes to selective neuronal vulnerability in Alzheimer's Disease.

Bryan A AdriaanseSinead BradyMinghui WangDaniel J BeardJonathan I SpencerJonathan PansieriBrad A SutherlandMargaret M EsiriAlastair M BuchanZameel CaderBin ZhangGabriele C DeLuca

Published in: Neuropathology and applied neurobiology (2023)

Our combined data point to TSC1 dysregulation as a key driver of selective neuronal vulnerability in the AD hippocampus. Future work aimed at identifying targets amenable to therapeutic manipulation is urgently needed to halt selective neurodegeneration, and by extension, debilitating cognitive impairment characteristic of AD.

Keyphrases

cognitive impairment
climate change
cerebral ischemia
current status
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electronic health record
big data
blood brain barrier
subarachnoid hemorrhage
artificial intelligence