Bioactivity and safety of B7-H3-targeted chimeric antigen receptor T cells against anaplastic meningioma.
Xin TangFujun LiuZhiyong LiuYi CaoZongliang ZhangYuelong WangJianhan HuangShuangming FanShasha ZhaoYaxing ChenGaowei LiShan WangMei-Jun ZhengYating HuHongjian LiCaiying JiangMeijia YangHui YangJianGuo XuGang GuoAiping TongLiangxue ZhouPublished in: Clinical & translational immunology (2020)
Our results suggested that although intracavitary administration of B7-H3-targeted CAR-T cells was safe and resulted in local bioactivity, addressing antigen loss and CAR-T-cell trafficking may further enhance the applications of B7-H3-targeted CAR-T-cell therapy.