The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model.

Sander van Riet Anais Julien Andrea AtanasovÅsa NordlingMagnus Ingelman-Sundberg

Published in: Hepatology communications (2024)

Potential anti-NASH drugs and compounds were evaluated for their efficacy in reducing collagen accumulation, and we found differences in specificity between spheroids with and without LSECs. This new human NASH model may reveal novel mechanisms for the regulation of liver fibrosis and provide a more appropriate model for screening drugs against NASH.

Keyphrases

endothelial cells
liver fibrosis
dna methylation
high glucose
drug induced
induced pluripotent stem cells
wound healing