B inflammatory pathway by inhibiting AKR1B1, resulting in reduced inflammatory cytokine levels in renal tissues and blood. This mitigated renal tissue injuries and improved the systemic inflammatory response in the severe sepsis rat model. Consequently, AKR1B1 holds promise as a target for treating sepsis-associated acute kidney injuries.
Keyphrases
- acute kidney injury
- inflammatory response
- septic shock
- cardiac surgery
- intensive care unit
- oxidative stress
- liver failure
- drug induced
- mass spectrometry
- signaling pathway
- lipopolysaccharide induced
- respiratory failure
- early onset
- big data
- toll like receptor
- machine learning
- immune response
- hepatitis b virus
- mechanical ventilation
- extracorporeal membrane oxygenation