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COVID-19 and the ethnicity link - is there a photochemical link?

Ruth EdgeT George Truscott
Published in: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (2021)
A hypothesis is proposed to explain the increased detrimental effect of COVID-19 for Black, Asian and Minority Ethnic (BAME) men and women compared to Caucasian individuals. This is based on the differing photochemistry of phaeomelanin in fair skin and eumelanin in dark/black skin. It is suggested that a range of reactive oxygen species, including, singlet oxygen and the superoxide radical anion, derived via direct photolysis of phaeomelanin, may escape the melanocyte and cause subsequent damage to the SARS-CoV-2 virus. It is further suggested that (large) carbon and sulphur peroxy radicals, from oxygen addition to radicals formed by carbon-sulphur bond cleavage, may assist via damage to the cell membranes. It is also speculated that light absorption by phaeomelanin and the subsequent C-S bond cleavage, leads to release of pre-absorbed reactive oxygen species, such as singlet oxygen and free radicals, which may also contribute to an enhanced protective effect for fair-skinned people.
Keyphrases
  • sars cov
  • reactive oxygen species
  • coronavirus disease
  • respiratory syndrome coronavirus
  • soft tissue
  • oxidative stress
  • wound healing
  • single cell
  • cell therapy
  • stem cells
  • nitric oxide
  • african american
  • energy transfer