Inhibition of proline-rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.

Ralf ErkensDragos Andrei DuseAmanda BrumAlexandra ChadtStefanie BecherMauro SiragusaChristine QuastJohanna MüssigMichael RodenMiriam M Cortese-Krott Francesco LavarraEckhard LammertIngrid FlemingChristian JungHadi Al-HasaniGerd HeuschMalte Kelm

Published in: British journal of pharmacology (2024)

Endothelial function and remote tissue protection are impaired in diabetes. Pyk2 is a novel target for treating endothelial dysfunction and restoring cardioprotection through rIPC in diabetes.

Keyphrases

type diabetes
tyrosine kinase
glycemic control
cardiovascular disease
epidermal growth factor receptor
insulin resistance
ischemia reperfusion injury
metabolic syndrome
adipose tissue
oxidative stress