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Role of the CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage.

Rafael M CostaDébora M CerqueiraAriane Bruder-NascimentoJuliano V AlvesWanessa Mayumi Carvalho AwataShubhnita SinghAlexander KufnerDouglas Silva PradoEbin JohnyEugenia Cifuentes-PaganoWilliam F HawsePartha DuttaPatrick J PaganoJacqueline HoThiago Bruder-Nascimento
Published in: Hypertension (Dallas, Tex. : 1979) (2024)
Our data demonstrate that CCL5/CCR5, through activation of NFκB and NOX1, is critically involved in aldosterone-induced vascular and renal damage and hypertension placing CCL5 and CCR5 as potential therapeutic targets for conditions characterized by aldosterone excess.
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