Adult intracranial ependymoma - relevance of DNA methylation profiling for diagnosis, prognosis and treatment.
Malte TrägerLeonille SchweizerPérez EilísSimone SchmidElisabeth G HainCarsten DittmayerJulia OnkenKohei FukuokaKoichi IchimuraUlrich SchüllerLasse DührsenMichael MütherWerner PaulusChristian ThomasMarielena Gutt-WillPhilippe SchuchtTheoni MaragkouCornelia BrendleFranziska EckertMaximilian NiyaziDaniel FleischmannMario DorostkarPetra FeyerSven-Axel MayDag MoskoppHarun BadakhshiCornelia RadkeJan WalterFelix EhretDavid CapperDavid KaulPublished in: Neuro-oncology (2023)
DNA methylation profiling improves diagnostic accuracy and risk stratification in adult intracranial ependymoma. The molecular class of PF-SE is unexpectedly prevalent among adult tumors with ependymoma histology and relapsed as frequently as EPN-PFB, despite the supposed benign nature. Gross total resection and radiotherapy may represent key factors in determining the outcome of EPN-PFB patients.
Keyphrases
- dna methylation
- end stage renal disease
- genome wide
- gene expression
- ejection fraction
- newly diagnosed
- chronic kidney disease
- early stage
- peritoneal dialysis
- single cell
- acute lymphoblastic leukemia
- prognostic factors
- optic nerve
- multiple myeloma
- young adults
- hodgkin lymphoma
- copy number
- patient reported
- replacement therapy