Uptake and Release of Species from Carbohydrate Containing Organogels and Hydrogels.
Abhishek PanSaswati G RoyUjjal HaldarRita D MahapatraGarry R HarperWan Li LowPriyadarsi DeJohn George HardyPublished in: Gels (Basel, Switzerland) (2019)
Hydrogels are used for a variety of technical and medical applications capitalizing on their three-dimensional (3D) cross-linked polymeric structures and ability to act as a reservoir for encapsulated species (potentially encapsulating or releasing them in response to environmental stimuli). In this study, carbohydrate-based organogels were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of a β-D-glucose pentaacetate containing methacrylate monomer (Ac-glu-HEMA) in the presence of a di-vinyl cross-linker; these organogels could be converted to hydrogels by treatment with sodium methoxide (NaOMe). These materials were studied using solid state 13C cross-polarization/magic-angle spinning (CP/MAS) NMR, Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FE-SEM). The swelling of the gels in both organic solvents and water were studied, as was their ability to absorb model bioactive molecules (the cationic dyes methylene blue (MB) and rhodamine B (RhB)) and absorb/release silver nitrate, demonstrating such gels have potential for environmental and biomedical applications.
Keyphrases
- solid state
- electron microscopy
- drug delivery
- drug release
- hyaluronic acid
- tissue engineering
- high resolution
- human health
- extracellular matrix
- wound healing
- healthcare
- gold nanoparticles
- nitric oxide
- risk assessment
- life cycle
- blood glucose
- type diabetes
- climate change
- staphylococcus aureus
- molecularly imprinted
- combination therapy
- magnetic resonance
- mass spectrometry
- escherichia coli
- aqueous solution
- insulin resistance
- fluorescent probe
- pseudomonas aeruginosa
- tandem mass spectrometry
- replacement therapy
- glycemic control