NRP1 antagonism as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis.
Roza KhalmuratovaJae-Sung RyuJi Hyeon HwangYi-Sook KimSuha LimJi-Hun MoJong-Yeup KimHyun-Woo ShinPublished in: Allergy (2024)
These findings reveal that NRP1 is upregulated in CRS and NP epithelium, and the inhibition of NRP1 may lead to a reduction in NP growth and immune cell infiltration. Our results suggest that NRP1 inhibition could be a novel possibility for treating nasal polyposis.